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The future of mutantkind has never looked so grim! Jamie Madrox, a.k.a. Multiple Man, and the enigmatic Layla Miller find themselves stranded eighty years in the future. Their mission: to find the cause of temporal anomalies that threaten to trigger the collapse of the legendary Summers Rebellion. If they fail, mutantkind as we know it will be wiped from history! They have only one chance of success. But to seize it, they'll need to get help from the most ruthless villain ever to blight the Marvel Universe: Victor von Doom! Back in the present, the maniacal Cortex is scheming to tear X-Factor apart. And he plans to use a flawlessly engineered killing machine to do it: former X-Factor ally Shatterstar! Little does Cortex know that Shatterstar has some unfinished romantic business with a member of the team. All's fair in love and war, but X-Factor is up against a guy who doesn't mind messing with time itself, if it proves the means to an end. The clock is ticking. Can even the world's greatest mutant detective agency save the past and the future? Collecting X-FACTOR #46-50 and X-FACTOR: LAYLA MILLER.